Δ‐Aminolevulinatedehydrase: synteny with ABO‐AK1‐ORM (and assignment to chromosome 9)

@article{Eiberg1983AminolevulinatedehydraseSW,
  title={$\Delta$‐Aminolevulinatedehydrase: synteny with ABO‐AK1‐ORM (and assignment to chromosome 9)},
  author={Hans Eiberg and Jan Mohr and Lillian Staub Nielsen},
  journal={Clinical Genetics},
  year={1983},
  volume={23}
}
A material comprising 846 normal families from the Copenhagen area (fam. no. 604–1505) was tested for δ‐aminolevulinatedehydrogenase. Among the 1697 unrelated individuals (parents), the gene frequencies were 0.9378 for ALADH*1 and 0.0622 for ALADH*2. The distribution of phenotypes and the segregation ratios did not deviate significantly from the expected values. Linkage analysis was carried out for markers on chromosome 9, following up a hint of ALADH‐ORM linkage in part of the material. This… 

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References

SHOWING 1-3 OF 3 REFERENCES

δ‐aminolevulinate dehydrase: a new genetic polymorphism in man

A method has been developed for the electrophoretic and quantitative analyses of human red cell δ‐aminolevulinate dehydrase (ALADH), under the control of an autosomal gene, with two common codominant alleles with frequencies of 0–89 and Oil, respectively.

The genetic polymorphism of Δ-aminolevulinate dehydrase in Italy

The distribution of phenotypic and allelic frequencies of red blood cells aminolevulinate dehydrase in several Italian populations is reported and the most common allele ALADH1 ranges from 0.78 to 0.93 with a mean value of 0.90±0.01.