Α-mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation.

@article{Wang2012mangostinAP,
  title={Α-mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation.},
  author={Yan Wang and Zheng Xia and Jian-rong Xu and Yan-xia Wang and Li-Na Hou and Yu Qiu and HongZhuan Chen},
  journal={Neuropharmacology},
  year={2012},
  volume={62 2},
  pages={871-81}
}
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of β-sheet-rich amyloid oligomers or fibrils which are associated with cellular toxicity in the brain. Inhibition of Aβ aggregation could be a viable therapeutic strategy for slowing and/or preventing the progress of AD. Here we reported that α-mangostin (α-M), a polyphenolic xanthone derivative from mangosteen, concentration-dependently attenuated the neurotoxicity induced by Aβ-(1-40) or A… CONTINUE READING

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