Α-glucosidase inhibitor isolated from coffee.

@article{Kim2015glucosidaseII,
  title={Α-glucosidase inhibitor isolated from coffee.},
  author={Shin Duk Kim},
  journal={Journal of microbiology and biotechnology},
  year={2015},
  volume={25 2},
  pages={174-7}
}
  • Shin Duk Kim
  • Published 2015 in Journal of microbiology and biotechnology
The potent α-glucosidase inhibitor (compound I) was isolated from coffee brews by the activity-based fractionation and identified as a β-carboline alkaloid norharman (9H-pyrido[ 3.4-b]indole) on the basis of mass spectroscopy and nuclear magnetic resonance spectra ((1)H NMR, (13)C NMR, and COSY). The norharman showed a potent inhibition against α-glucosidase enzyme in a concentration dependent manner with an IC50 value of 0.27 mM for maltase and 0.41 mM for sucrase, respectively. A Lineweaver… CONTINUE READING

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