ŌvSim: a Simulation of the Population Dynamics of Mammalian Ovarian Follicles

@article{Johnson2016vSimAS,
  title={ŌvSim: a Simulation of the Population Dynamics of Mammalian Ovarian Follicles},
  author={Joshua Johnson and Xin Chen and Xiao Xu and John W. Emerson},
  journal={bioRxiv},
  year={2016}
}
No two ovaries are alike, and indeed, the same ovary can change its architecture from day to day. This is because ovarian follicles are present in different numbers, positions, and states of maturation throughout reproductive life. All possible developmental states of follicles can be represented at any time, along with follicles that have committed to death (termed follicle atresia). Static histological and whole-mount imaging approaches allow snapshots of what is occurring within ovaries, but… Expand

References

SHOWING 1-10 OF 61 REFERENCES
Development of follicles in the mammalian ovary.
  • A. Hirshfield
  • Biology, Medicine
  • International review of cytology
  • 1991
TLDR
This chapter discusses the development of follicles in the mammalian ovary, a complex, functional miniature organ arises from the handful of cells that constitute a simple primordial follicle, a structure so small that it is invisible at the lower magnifications of a light microscope. Expand
Follicle dynamics and global organization in the intact mouse ovary.
Quantitative analysis of tissues and organs can reveal large-scale patterning as well as the impact of perturbations and aging on biological architecture. Here we develop tools for imaging of singleExpand
Germline stem cells and follicular renewal in the postnatal mammalian ovary
TLDR
The investigators identified genes whose expression is necessary for replicating germ cells to produce oocytes for follicle formation in postnatal life and suggest that GSCs are present in the postnatal mouse ovary. Expand
Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply.
TLDR
The hypothesis of postnatal follicle renewal in postnatal and adult ovaries of C57BL/6 mice is supported and no evidence for ovarian germline stem cells is found. Expand
Computer-Generated Ovaries to Assist Follicle Counting Experiments
TLDR
Computer algorithms are developed, which generate models of neonatal mouse ovaries (simulated ovaries), with characteristics derived from experimental measurements already available in the published literature, which are used to reproduce in-silico counting experiments based on unbiased stereological techniques. Expand
Ovarian follicular growth, ovulation and atresia. Endocrine, paracrine and autocrine regulation.
TLDR
This chapter describes a finely tuned series of events that results in ovarian morphological changes including follicular growth, dominant follicle selection, oocyte development, ovulation, and corpus luteum formation and describes the explosion of data on intracellular and intranuclear regulators. Expand
Ovarian follicle counts – not as simple as 1, 2, 3
  • J. Tilly
  • Biology, Medicine
  • Reproductive biology and endocrinology : RB&E
  • 2003
TLDR
A large number of studies have shown that exposure of the ovaries to a variety of pathological insults, such as anticancer therapies and environmental toxicants, accelerates oocyte and follicle depletion, consequently hastening the time at which ovarian failure is observed. Expand
Involvement of apoptosis in ovarian follicular atresia and postovulatory regression.
TLDR
The present findings provide a basis for elucidating the hormonal signals involved in the initiation of follicular atresia during follicle recruitment, reproductive aging and premature ovarian failure. Expand
Anti-Müllerian Hormone Inhibits Initiation of Primordial Follicle Growth in the Mouse Ovary.
TLDR
It is suggested that AMH inhibits initia- tion of primordial follicle growth and therefore functions as an inhibitory growth factor in the ovary during these early stages of folliculogenesis. Expand
Germline stem cells and follicular renewal in the postnatal mammalian ovary
TLDR
It is shown that juvenile and adult mouse ovaries possess mitotically active germ cells that, based on rates of oocyte degeneration (atresia) and clearance, are needed to continuously replenish the follicle pool. Expand
...
1
2
3
4
5
...