ŌvSim: a Simulation of the Population Dynamics of Mammalian Ovarian Follicles

  title={ŌvSim: a Simulation of the Population Dynamics of Mammalian Ovarian Follicles},
  author={Joshua Johnson and Xin Chen and Xiao Xu and John W. Emerson},
No two ovaries are alike, and indeed, the same ovary can change its architecture from day to day. This is because ovarian follicles are present in different numbers, positions, and states of maturation throughout reproductive life. All possible developmental states of follicles can be represented at any time, along with follicles that have committed to death (termed follicle atresia). Static histological and whole-mount imaging approaches allow snapshots of what is occurring within ovaries, but… Expand


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This chapter discusses the development of follicles in the mammalian ovary, a complex, functional miniature organ arises from the handful of cells that constitute a simple primordial follicle, a structure so small that it is invisible at the lower magnifications of a light microscope. Expand
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Quantitative analysis of tissues and organs can reveal large-scale patterning as well as the impact of perturbations and aging on biological architecture. Here we develop tools for imaging of singleExpand
Germline stem cells and follicular renewal in the postnatal mammalian ovary
The investigators identified genes whose expression is necessary for replicating germ cells to produce oocytes for follicle formation in postnatal life and suggest that GSCs are present in the postnatal mouse ovary. Expand
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This chapter describes a finely tuned series of events that results in ovarian morphological changes including follicular growth, dominant follicle selection, oocyte development, ovulation, and corpus luteum formation and describes the explosion of data on intracellular and intranuclear regulators. Expand
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A large number of studies have shown that exposure of the ovaries to a variety of pathological insults, such as anticancer therapies and environmental toxicants, accelerates oocyte and follicle depletion, consequently hastening the time at which ovarian failure is observed. Expand
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