Über humorale Übertragbarkeit der Herznervenwirkung

  title={{\"U}ber humorale {\"U}bertragbarkeit der Herznervenwirkung},
  author={Otto Loewi and Ernst Navratil},
  journal={Pfl{\"u}ger's Archiv f{\"u}r die gesamte Physiologie des Menschen und der Tiere},
  • O. Loewi, E. Navratil
  • Published 1 December 1926
  • Chemistry
  • Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere
A historic perspective on the current progress in elucidation of the biologic significance of non-neuronal acetylcholine.
The progress made has opened a new chapter in the field of cholinergic pharmacology, and advanced the authors' knowledge beyond regulation of individual cell- and tissue-types, defining a new paradigm of selective pharmacological regulation of vital function of practically all types of non-neuronal cells. Expand
History of ectonucleotidases and their role in purinergic signaling.
A short overview traces the development of ectoenzymes with broad substrate specificity and briefly highlights important results and benefits for therapies of human diseases achieved within nearly a century of investigations. Expand
The Mouse Brainstem (Truncus encephali)
The mammalian brainstem is composed in caudocranial order of the medulla oblongata, the pons, and the midbrain (mesencephalon), and the main difference to the spinal cord is the endowment of the brainstem with nuclei, fiber tracts, and nerves for the innervation of the head-specific organs. Expand
A Novel Antiserum Against a Predicted Human Peripheral Choline Acetyltransferase (hpChAT) for Labeling Neuronal Structures in Human Colon
The present results demonstrate the specificity and reliability of the hpChAT antiserum as a novel tool for immunohistochemical studies in human colon, opening venues to map cholinergic innervation in other human PNS tissues. Expand
Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses
Current attempts to prevent and/or treat AD are addressed in light of advances in understanding pathogenetic mechanisms and it is suggested that studies in the DS population may provide unique insights into AD pathogenesis and treatment. Expand
Cholinesterases and the fine line between poison and remedy
Non‐catalytic functions of the cholinesterases (ChEs) participate in both neurodevelopment and disease, and Manipulating either the catalytic activities or the structure of these enzymes can potentially shift the balance between beneficial and adverse effect in a wide number of physiological processes. Expand
Homeostatic systems, biocybernetics, and autonomic neuroscience
It is proposed that disintegration of homeostatic systems causes disorders of regulation in degenerative diseases and that medical cybernetics can inspire and rationalize new approaches to treatment and prevention. Expand
Non‐neuronal acetylcholine involved in reproduction in mammals and honeybees
It is shown that non‐neuronal ACh is substantially involved in the regulation of reproduction in mammals and also non‐mammals like insects (honeybees) and adverse effects of the neonicotinoids, a class of world‐wide applied insecticides. Expand