Über die Bildung eines blaugrünen, biliverdinartigen Farbstoffes in hämoglobinhaltigem Urin
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TUMOR MARKERS oTumor index substances – released from the tumor cells, which could be detected in blood and indicate the presence of tumor in the body o Used for the follow-up of cancer and to monitor the effectiveness of the therapy o Diagnosis of cancer o Prognostic use o Localization CLINICALLY IMPORTANT TUMOR MARKERS: 1. AFP (alpha fetoprotein): Molecular weight = 70,000 Daltons It is a fetal albumin Increased values are seen in the circulation of patients with hepatocellular carcinoma, germ cell tumors, teratocarcinoma of ovary and in pregnancy with fetal malformations of neural tube 2. CARCINOEMBRYONIC ANTIGEN (CEA): Its level is markedly increased in colorectal cancers 3. PROSTATIC SPECIFIC ANTIGEN (PSA): Produced by secretary epithelium of prostatic gland It is normally secreted in to seminal fluid, where it is necessary for the liquifaction of seminal coagulum Increased PSA level is seen in prostate cancer 4. BETA CHAIN OF CHORIONIC GONADOTROPHIN: It is synthesised by normal syncytiotrophoblasts (cells of placental villi) The hCG has alpha and beta subunits Increased levels are seen in choriocarcinoma and germ cell tumors
Sep 06, 2017