Ätiologie und Pathophysiologie des Fibromyalgiesyndroms

@article{Sommer2012tiologieUP,
  title={{\"A}tiologie und Pathophysiologie des Fibromyalgiesyndroms},
  author={Claudia Sommer and Winfried H{\"a}user and Markus Burgmer and Rolf Engelhardt and Kerstin Gerhold and Frank Petzke and Tobias Schmidt-Wilcke and Michael Sp{\"a}th and Thomas R. T{\"o}lle and Nurcan {\"U}çeyler and H. Wang and Andreas Winkelmann and Kati Thieme},
  journal={Der Schmerz},
  year={2012},
  volume={26},
  pages={259-267}
}
ZusammenfassungHintergrundDie planmäßige Aktualisierung der S3-Leitlinie zum Fibromyalgiesyndrom (FMS; AWMF-Registernummer 041/004) wurde ab März 2011 vorgenommen.Material und MethodenDie Leitlinie wurde unter Koordination der Deutschen Interdisziplinären Vereinigung für Schmerztherapie (DIVS) von 9 wissenschaftlichen Fachgesellschaften und 2 Patientenselbsthilfeorganisationen entwickelt. Acht Arbeitsgruppen mit insgesamt 50 Mitgliedern wurden ausgewogen in Bezug auf Geschlecht, medizinischen… 
Allgemeine Behandlungsgrundsätze, Versorgungskoordination und Patientenschulung beim Fibromyalgiesyndrom
TLDR
The regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was scheduled for April 2017 and the strength of recommendations was achieved by multiple step formalized procedures to reach a consensus.
Das Fibromyalgiesyndrom als psychosomatische Erkrankung - Empfehlungen aktueller evidenzbasierter Leitlinien zu Diagnostik und Therapie
Zusammenfassung Fragestellung: Die Klassifikation und Therapie von Patienten mit chronischen Schmerzen in mehreren Korperregionen ohne hinreichend erklarenden somatischen Krankheitsfaktor ist
Stellenwert der Patientenschulung für Patientinnen und Patienten mit Fibromyalgie-Syndrom
TLDR
Es konnte eine Rangliste der haufigsten Nennungen erstellt werden, sodass die Inhalte Eingang in die Neukonzeption des Schulungsprogramms fanden.
Schmerz ist modalitätsspezifisch
TLDR
Interoceptive visceral pain is perceived as more fear-inducing and unpleasant compared to cutaneous heat pain in healthy women even when stimuli are matched for perceived pain intensity even when results are controlled for intra-individual differences in perceivedPain intensity.
Fibromyalgiesyndrom – Bedeutung für die Rehabilitation
TLDR
Thiser Beitrag soll konkrete Hinweise zu Krankheitskonzept, Diagnostik, Therapie, Rehabilitation and sozialmedizinischer Beurteilung beim FMS geben.
Das Fibromyalgiesyndrom – FMS
TLDR
Entsprechende Fragebogen, Diagnosekriterien und die S3-Leitlinie Fibromyalgiesyndrom unterstutzen darin, das FMS zu erkennen and zu therapieren, dass Patienten adaquat behandelt werden.
[Fibromyalgia syndrome. Definition, classification, clinical diagnosis and prognosis].
TLDR
The clinical diagnosis of FMS can be established by the American College of Rheumatology 1990 classification criteria, by the modified preliminary diagnostic ACR 2010 criteria or by the diagnostic criteria of the German interdisciplinary guideline (AWMF) on FMS.
12 Jahre S3-Leitlinie Fibromyalgiesyndrom – ein nie endender Krieg?
1 Klinik Innere Medizin I (Gastroenterologie, Hepatologie, Stoffwechselund Infektionskrankheiten, Psychosomatik), Klinikum Saarbrücken gGmbH, Saarbrücken, Deutschland Deutsche Rheuma-Liga, Ellwangen,
[Etiology and pathophysiology of fibromyalgia syndrome : Updated guidelines 2017, overview of systematic review articles and overview of studies on small fiber neuropathy in FMS subgroups].
TLDR
Fibromyalgia syndrome is most probably the end result of various pathogenetic factors and pathophysiological mechanisms and is likely to be associated with inflammatory rheumatic diseases, gene polymorphisms, life style factors and depressive disorders in childhood and adulthood.
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References

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Ätiopathogenese und Pathophysiologie des Fibromyalgiesyndroms und chronischer Schmerzen in mehreren Körperregionen
TLDR
An interdisciplinary level-3 guideline for the diagnosis and therapy of FMS was created in cooperation with 10 medical and psychological societies and 2 patient self-help organizations and Consensus was achieved by a multi-step nominal group procedure.
Zentrale Schmerzverarbeitung bei funktionellen somatischen Syndromen
TLDR
Functional pain syndromes usually are characterized by a local or generalized increase in pain sensitivity, spontaneous ongoing pain, and a variety of other common symptoms, resulting in significant overlap between conditions.
A subset of fibromyalgia patients have findings suggestive of chronic inflammatory demyelinating polyneuropathy and appear to respond to IVIg.
TLDR
A significant subset of FMS subjects have clinical and EDX findings suggestive of chronic inflammatory demyelinating polyneuropathy (CIDP), and IVIg treatment shows promise in treating this subset.
A painful train of events: increased prevalence of fibromyalgia in survivors of a major train crash.
TLDR
Fibromyalgia was found to be highly prevalent, three years after a major train crash, among individuals exposed to the combination of physical injury and extreme stress.
Pathophysiology of fibromyalgia.
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Systematic review with meta-analysis: cytokines in fibromyalgia syndrome
TLDR
Systematic review of the selected 25 articles revealed that FMS patients had higher serum levels of interleukin (IL)-1 receptor antagonist, IL-6, and IL-8, and higher plasma levels of IL- 8, and meta-analysis of eligible studies showed that F MS patients hadHigher plasma IL- 6 levels compared to controls.
Candidate gene studies of fibromyalgia: a systematic review and meta-analysis
TLDR
This meta-analysis demonstrates that the 5-HT2A receptor 102T/C polymorphism confers susceptibility to fibromyalgia.
Anxiety and depressive symptoms in fibromyalgia are related to poor perception of health but not to pain sensitivity or cerebral processing of pain.
TLDR
Evidence is provided that 2 partially segregated mechanisms are involved in the neural processing of experimental pain and negative affect and that negative mood in FM patients can lead to a poor perception of one's physical health but does not influence performance on assessments of clinical and experimental pain.
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