{beta}-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle.

@article{Yamada2010betaHydroxybutyrateII,
  title={\{beta\}-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle.},
  author={Takashi Yamada and S Zhang and H{\aa}kan Westerblad and Abram Katz},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={299 3},
  pages={E364-73}
}
Blood ketone body levels increase during starvation and untreated diabetes. Here we tested the hypothesis that ketone bodies directly inhibit insulin action in skeletal muscle. We investigated the effect of d,l-beta-hydroxybutyrate (BOH; the major ketone body in vivo) on insulin-mediated glucose uptake (2-deoxyglucose) in isolated mouse soleus (oxidative) and extensor digitorum longus (EDL; glycolytic) muscle. BOH inhibited insulin-mediated glucose uptake in soleus (but not in EDL) muscle in a… CONTINUE READING
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