[p53 gene mutation in cancer of the colon and rectum].

@article{Roa2000p53GM,
  title={[p53 gene mutation in cancer of the colon and rectum].},
  author={Juan Carlos S Roa and Ivan S. Roa and Ang{\'e}lica Melo and Juan Araya and Miguel Angel Villaseca and M. Flores and Bj{\"o}rn Schneider},
  journal={Revista medica de Chile},
  year={2000},
  volume={128 9},
  pages={996-1004}
}
BACKGROUND Genetic events associated to colorectal carcinoma are well characterized, but there is scanty information about this issue in Chilean subjects. AIM To determine the frequency and distribution of exons 5, 6, 7, 8 and 9 mutations and the immunohistochemical expression of p53 gene in biopsy samples of colorectal carcinoma. MATERIAL AND METHODS p53 gene exons 5, 6, 7, 8 and 9 were directly sequenced in 42 biopsy samples of colorectal carcinoma. Immunohistochemical expression of p53… CONTINUE READING