[p53 gene abnormalities in advanced primary lung cancer and metastatic tumors].

Abstract

To study the relation between p53 mutation and metastasis in primary lung cancer, 29 pairs of primary and metastatic tumors obtained by autopsy were analyzed for abnormalities of the p53 gene, by the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP). The tumors consisted of 6 small cell carcinomas, 13 adenocarcinomas, 8 squamous… (More)

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