• Biology, Medicine
  • Published in
    Zhonghua zhong liu za zhi…
    2001

[beta-elemene induces apoptosis of K562 leukemia cells].

@article{Zou2001betaelemeneIA,
  title={[beta-elemene induces apoptosis of K562 leukemia cells].},
  author={Li-Juan Zou and Weijun Liu and Li-qun Yu},
  journal={Zhonghua zhong liu za zhi [Chinese journal of oncology]},
  year={2001},
  volume={23 3},
  pages={
          196-8
        }
}
OBJECTIVE To investigate the apoptosis-inducing effect of beta-elemene on K562 leukemia cells. METHODS Hoechst 33342 and PI fluorescence staining, DNA fragmentation, electron microscopy, flow cytometry, and immunocytochemistry were used to evaluate the effect of beta-elemene on K562 cells. RESULTS beta-elemene heatment induced the formation of apoptotic bodies and DNA ladder. The effect was dose- and time-dependent. The expression of bcl-2 was decreased in beta-elemene treated cells as… CONTINUE READING

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