[ZGDHu-1-inducing apoptosis of SHI-1 leukemia cells and its molecular mechanism].

  title={[ZGDHu-1-inducing apoptosis of SHI-1 leukemia cells and its molecular mechanism].},
  author={Yong-Lie Zhou and Ya-ping L{\"u} and Wei-xiao Hu and Lian-n{\"u} Qiu and Wen-song Wang and Jian-dong Liu and Jianguo Wu},
  journal={Zhongguo shi yan xue ye xue za zhi},
  volume={15 3},
The aim of study was to investigate the mechanism of N, N'-di-(m-methylphenyl)-3, 6-dimethyl-1, 4-dihydro-1, 2, 4, 5-tetrazine-1, 4-dicarboamide (ZGDHu-1) inducing apoptosis in SHI-1 human leukemia cell line. Different concentrations of ZGDHu-1 and different times of culture were used to treat SHI-1 cells; the apoptosis of SHI-1 cells was analyzed by morphology, DNA agarose gel electrophoresis, DNA content detection, Annexin-V/PI and Hoechst33258 labeling method, the mitochondrial transmembrane… CONTINUE READING
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