[YKL 40: marker of disease activity in rheumatoid arthritis?].

  title={[YKL 40: marker of disease activity in rheumatoid arthritis?].},
  author={Micaela Morgante and Ombretta di Munno and Dominic Morgante},
  journal={Minerva medica},
  volume={90 11-12},
In patients with rheumatoid arthritis the serum and synovial fluid levels of a glycoprotein called YKL 40 are correlated to the severity of disease. YKL 40 may be related to disease activity in RA; it is induced by vitamine D and is reduced by TGF b. YKL 40 has been isolated from bovine mammary secretions during non lactating period and from Human osteosarcoma cell line MG-63. Some observations on experimental and clinical studies are presented.