[Viral vectors for gene delivery to corneal endothelial cells].

  title={[Viral vectors for gene delivery to corneal endothelial cells].},
  author={Thomas Armin Fuchsluger and Ula V Jurkunas and Andrius Kazlauskas and Reza Dana},
  journal={Klinische Monatsblatter fur Augenheilkunde},
  volume={228 6},
BACKGROUND Corneal endothelium is an interesting target for in vitro gene transfer strategies as it is readily accessible thanks to its anatomic structure as a monolayer and its direct contact to culture medium. Whereas the use of adenoviruses as viral vectors (carriers) to endothelial cells (EC) has been described as problematic as to its immunogenicity, lentiviruses and adeno-associated viruses (AAV) are potent vectors for the transfer of genetic DNA into EC. Lentiviral vectors, developed on… CONTINUE READING


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