Corpus ID: 24610066

[Usefulness of immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A for diagnosing in two sisters with May-Hegglin anomaly].

@article{Kimura2008UsefulnessOI,
  title={[Usefulness of immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A for diagnosing in two sisters with May-Hegglin anomaly].},
  author={N. Kimura and M. Matsumoto and Katsuya Matsumoto and Norihiko Asai and S. Kunishima},
  journal={[Rinsho ketsueki] The Japanese journal of clinical hematology},
  year={2008},
  volume={49 12},
  pages={
          1614-8
        }
}
May-Hegglin anomaly (MHA) is a rare autosomal dominant disorder characterized by thrombocytopenia, giant platelets, and unique leukocyte inclusion bodies. The diagnosis of MHA has been made by identifying leukocyte inclusion bodies on May-Giemsa stained blood film, however, it is not always easy to detect these findings. Therefore, patients with MHA are often misdiagnosed and managed as having idiopathic thrombocytopenic purpura. MHA is caused by mutations in the MYH9 gene, which encodes the… Expand
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