[Upstream signaling pathway of neutrophil elastase-induced mucous hypersecretion].

Abstract

OBJECTIVE To investigate the upstream signal transduction pathway of neutrophil elastase (NE)-induced mucous hypersecretion via epidermal growth factor receptor (EGFR). METHODS The airway epithelial cells of the line BEAS-2B were cultured and divided into 6 groups: control group, cultured in serum-free DMEM/Ham's F12 mixture; NE group, incubated with NE… (More)

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