[Trisomy 21: fifty years between medicine and science].

@article{Turleau2010Trisomy2F,
  title={[Trisomy 21: fifty years between medicine and science].},
  author={Catherine Turleau and Michel Vekemans},
  journal={Medecine sciences : M/S},
  year={2010},
  volume={26 3},
  pages={267-72}
}
Fifty years after the discovery of the etiology of Down syndrome, trisomy 21 remains the model of choice for studying human diseases resulting from the presence of a chromosome or a chromosome segment in excess. In this review, mechanisms of aneuploidy occurrence and consequences of genomic imbalances will be mainly discussed. The study of genetic markers… CONTINUE READING