[Triptolide combined with irbesartan synergistically blocks podocyte injury in a type 2 diabetes rat model].

@article{Ma2012TriptolideCW,
  title={[Triptolide combined with irbesartan synergistically blocks podocyte injury in a type 2 diabetes rat model].},
  author={Rui-xia Ma and Yan Xu and Juan Zhang and Yu-shan Li and Li-qiu Liu},
  journal={Zhonghua nei ke za zhi},
  year={2012},
  volume={51 2},
  pages={
          117-22
        }
}
OBJECTIVE To investigate the protective effect of combination of triptolide and irbesartan on the podocytes in a type 2 diabetic(T2DM) rat model, and evaluate its mechanism. METHODS T2DM rats were induced by fed with high-sucrose-high-fat diet combined with a low dose of streptozocin. The rats were randomly divided into 5 groups: normal control group (NC, n = 10), diabetes group (DM, n = 11), triptolide treatment group (DT, n = 12), irbesartan treatment group (DI, n = 12) and triptolide… CONTINUE READING