[Total synthesis of marine cyclic guanidine compounds and development of novel guanidine type asymmetric organocatalysts].

  • Kazuo Nagasawa
  • Published 2003 in
    Yakugaku zasshi : Journal of the Pharmaceutical…


Crambescidins and batzelladines, novel marine guanidine alkaloids, have unique pentacyclic and tricyclic guanidine core structures, respectively. They display a considerable array of biological activity and not surprisingly have attracted considerable synthetic interest. The first total synthesis of crambescidin 359 (7) and stereoselective total synthesis… (More)

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