• Corpus ID: 30559994

[Therapy of arrhythmia induced by myocardial ischemia. Association of L-carnitine, propafenone and mexiletine].

@article{Mondillo1995TherapyOA,
  title={[Therapy of arrhythmia induced by myocardial ischemia. Association of L-carnitine, propafenone and mexiletine].},
  author={Sergio Mondillo and Sergio Faglia and N D'Aprile and Liliana Mangiacotti and M A Campolo and Eustachio Agricola and Vincenzo Palazzuoli},
  journal={La Clinica terapeutica},
  year={1995},
  volume={146 12},
  pages={
          769-74
        }
}

• S. Mondillo, S. Faglia, +4 authors V. Palazzuoli
• Published 1 December 1995
• Medicine, Biology
• La Clinica terapeutica

To assess the anti-arrythmic effect of L-carnitina, propafenone and mexiletine, we tested the drugs in 50 patients with effort angina and ventricular ectopic beats (VEB). The patients were randomized in 5 groups: Group A: was treated with oral L-carnitine at the dose of 2 g x 3 for two weeks. Group B: oral propafenone at the dose of 300 mg x 3 for two weeks. Group C: as group B+L-carnitine+g x 3 at the second weeks. Group D: oral mexiletine at the dose of 200 mg x 3 for two weeks. Group E: as group D+L-carnitine 2 gr x 3 at the second week. After 7 and 14 days of treatment, in all patients an Holter examination was performed. Our results show that L-carnitine exerts a significant reduction of the VEB and its administration potentiates the anti-arrythmic effect of propafenone and mexiletine.