• Corpus ID: 30559994

[Therapy of arrhythmia induced by myocardial ischemia. Association of L-carnitine, propafenone and mexiletine].

  title={[Therapy of arrhythmia induced by myocardial ischemia. Association of L-carnitine, propafenone and mexiletine].},
  author={Sergio Mondillo and Sergio Faglia and N D'Aprile and Liliana Mangiacotti and M A Campolo and Eustachio Agricola and Vincenzo Palazzuoli},
  journal={La Clinica terapeutica},
  volume={146 12},
To assess the anti-arrythmic effect of L-carnitina, propafenone and mexiletine, we tested the drugs in 50 patients with effort angina and ventricular ectopic beats (VEB). The patients were randomized in 5 groups: Group A: was treated with oral L-carnitine at the dose of 2 g x 3 for two weeks. Group B: oral propafenone at the dose of 300 mg x 3 for two weeks. Group C: as group B+L-carnitine+g x 3 at the second weeks. Group D: oral mexiletine at the dose of 200 mg x 3 for two weeks. Group E: as… 
Effects of L‐carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin‐diabetic rat aorta
It is suggested that the beneficial effects of L‐carnitine treatment partially improve vascular reactivity and antioxidant property beyond its reduction of plasma lipids and it may have an important therapeutic approach in the treatment of diabetic vascular complications.
Integrated Approach to Arrhythmias
The clinical pictures fall into two broad categories: those that cause acute and transient electrophysiological abnormalities and those who, being chronic, provide the substrate for persistent or recurrent arrhythmias.
Endothelium‐dependent vasorelaxation induced by L‐carnitine in isolated aorta from normotensive and hypertensive rats
Results show that L‐carnitine induced endothelium‐dependent relaxation in the rat aorta and the mechanism of this relaxation appeared to be mostly mediated by endothelial production of nitric oxide but also could involve prevention of the action of cyclooxygenase endothelial products acting on the thromboxane A2/prostaglandin H2 receptor.
L-Carnitine: therapeutic applications of a conditionally-essential amino acid.
  • G. Kelly
  • Medicine, Biology
    Alternative medicine review : a journal of clinical therapeutic
  • 1998
Although available data on L-carnitine as an ergogenic aid is not compelling, under some experimental conditions pretreatment has favored aerobic processes and resulted in improved endurance performance.
Rapid and sensitive determination of carnitine profiling by tandem mass spectrometry can be a diagnostic marker of paroxysmal atrial fibrillation
  • I. Koyuncu
  • Medicine
    Journal of Clinical and Analytical Medicine
  • 2018
The results of the study strengthened the view that with measurements made with LCMS/MS, the carnitine profile, which is an inexpensive, sensitive reference method, can be used as an objective biochemical test to support diagnosis.