[Therapeutic effects of larger doses of arachidonic acid added to DHA on social impairment and its relation to alterations of polyunsaturated fatty acids in individuals with autism spectrum disorders].

@article{Yui2011TherapeuticEO,
  title={[Therapeutic effects of larger doses of arachidonic acid added to DHA on social impairment and its relation to alterations of polyunsaturated fatty acids in individuals with autism spectrum disorders].},
  author={Kunio Yui and Mamiko Koshiba and Shun Nakamura and Masako Onishi},
  journal={Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology},
  year={2011},
  volume={31 3},
  pages={
          117-24
        }
}
The polyunsaturated fatty acids (PUFAs), arachidonic acid (ARA) and docosahexaenoic acid (DHA) may play key roles in brain network maturation. ARA plays an important role in signal transduction related to neuronal maturation. This study aims to evaluate the efficacy of supplementing with larger doses of ARA added to DHA in a double-blind, placebo-controlled 16-week trial. To confirm findings observed in the placebo-controlled trial, an additional 16-week open-label study was further conducted… CONTINUE READING