[Theoretical and experimental studies on the conformation of the hinge regions in human immunoglobulin G subclasses].

@article{Denesiuk1983TheoreticalAE,
  title={[Theoretical and experimental studies on the conformation of the hinge regions in human immunoglobulin G subclasses].},
  author={A I Denesiuk and V. M. Tishchenko and Vyacheslav M. Abramov and V P Zav'ialov},
  journal={Molekuliarnaia biologiia},
  year={1983},
  volume={17 6},
  pages={1262-71}
}
Using the methods of difference adiabatic scanning microcalorimetry and difference thermal perturbation spectrophotometry it was established that both the Fc subunits within the intact immunoglobulins G of different subclasses, and the Fc fragments corresponding to them significantly differ in conformational properties. These differences are associated with a different energy of interactions between the CH2 and CH3 domains and also with a different rigidity of structure of the N- and C-terminal… CONTINUE READING