[The structure of degradation products of neostigmine bromide].

Abstract

In aqueous temperature-stressed solutions of neostigmine bromide besides the known product of hydrolysis additional degradation products were discovered, detected by TLC and HPLC. By means of spectroscopic studies (1H-NMR, IR, UV, MS) and elemental analysis the isolated decomposition products were identified as 3-hydroxyphenyltrimethylammonium bromide (2… (More)

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