[The role of transforming growth factor-beta1/Smad3 signaling in bronchiolitis obliterans following lung transplantation].

Abstract

OBJECTIVE To investigate the mechanism underlying bronchiolitis obliterans (OB) following lung transplantation and the significance of transforming growth factor (TGF)-beta1/Smad3 signal pathway in this pathological process. METHODS The tracheas of BALB/c mice were transplanted into the subcutaneous tissues of a Smad3ex8/ex8 gene knock-out Swiss black… (More)

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