• Corpus ID: 25183988

[The role of natural dietary compounds in colorectal cancer chemoprevention].

  title={[The role of natural dietary compounds in colorectal cancer chemoprevention].},
  author={Anna Olejnik and Joanna Tomczyk and Katarzyna Kowalska and Włodzimierz Grajek},
  journal={Postepy higieny i medycyny doswiadczalnej},
This review discusses the preventive and therapeutic potential of natural dietary compounds against colorectal cancer. The chemopreventive properties of many natural food matrices and purified bioactive compounds have been evaluated. Prominent among the dietary constituents that are the focus of interest in colorectal cancer chemoprevention are dietary fiber, probiotics and prebiotics, methionine and folate, vitamins D and E, calcium and selenium, anthocyanins, procyanidins, phytoestrogens… 

Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability.

This review summarizes the latest research in cancer chemoprevention and treatment using the bioactive components from natural plants and relevant molecular mechanisms involved in the pharmacological effects of these phytochemicals are discussed.

Flavonoids--food sources and health benefits.

It seems that a diet rich in flavonoids is beneficial and its promotion is thus justifiable, however further clinical and epidemiological trials are greatly needed.

Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives.

Evidence of the role of probiotic in modulating the microbiota, in improving the physico-chemical conditions of the gut and in reducing oxidative stress is described and the mechanisms of probiotics in inhibiting tumour progression, in producing anticancer compounds and inmodulating the host immune response are discussed.

Flavonoid and cannabinoid impact on the ocular surface.

Flavonoids and cannabinoids show promise as potential complementary treatment for allergic diseases because of their anti-inflammatory and antiallergic properties and show potential in becoming adjuvant treatment strategies for improving quality of life while also managing ocular surface disease processes.

Effects of enriched environment and probiotics on the intestinal mucosal barrier and the brain-gut axis in rats with colorectal cancer

The effect of enriched environment was better than probiotic, especially in the intestinal mucosal immune and biological barrier in rats with colorectal cancer, however, the combination of the two was not as effective as enriched environment.

Effects of Probiotics on Intestinal Mucosa Barrier in Patients With Colorectal Cancer after Operation

Probiotics can effectively protect the intestinal mucosa physical and biological barrier in patients with colorectal cancer after operation, however, to evaluate the protective effect on intestinal mucosal barrier, further studies on the type and concentration of the probiotics, duration of therapy, and the therapeutic route are required.

Effects of different environmental intervention durations on the intestinal mucosal barrier and the brain-gut axis in rats with colorectal cancer

The effect of an 8-week environmental intervention duration on the intestinal mucosal barrier was better than that of 2-week and 4-week durations overall, but the effect of different environmental intervention durations on brain-gut peptide levels was not obvious.

Recent Advances in Colorectal Cancer Research: The Microenvironment Impact

The key topics that characterize the insidious synergistic crosstalk between colon cancer and their microenvironment are reviewed in this special issue of Cancer Microenvironment.

Biocompounds content in organic and conventional raspberry fruits

Raspberry fruits are a source of vitamin C, phenolic acids and flavonoids, including anthocyanins. There is scientific evidence that allows to assume that organic fruit and vegetables contain more



Enhancement of experimental colon cancer by genistein.

The results of this investigation emphasize that the biological effects of genistein may be organ specific, inhibiting cancer development in some sites yet showing no effect or an enhancing effect on the tumorigenesis at other sites, such as the colon.

Berry fruits for cancer prevention: current status and future prospects.

  • N. Seeram
  • Biology, Medicine
    Journal of agricultural and food chemistry
  • 2008
This paper focuses on those commonly consumed in North America, namely, blackberries, black raspberries, blueberries, cranberries, red rasp berries, and strawberries, and focuses on studies of "whole berries" per se, that is, as berry extracts and purified fractions, juices, and freeze-dried powders.

Anthocyanin-Rich Extracts Inhibit Multiple Biomarkers of Colon Cancer in Rats

The results support the previous in vitro studies suggesting a protective role of AREs in colon carcinogenesis and indicate multiple mechanisms of action.

Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries.

This review article summarizes laboratory and human studies, demonstrating the protective effects of berries and berry constituents on oxidative and other cellular processes leading to cancer development.

Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents.

Measurement of leukocyte COX-2 activity should be considered in clinical trials of other agents likely to inhibit this isozyme, as well as in clinical Trials of many chemopreventive drugs known to inhibitThis enzyme.

Estrogens, phytoestrogens and colorectal neoproliferative lesions

Phytoestrogens are plant-derived compounds that structurally and functionally act as estrogen-agonists in mammals that are characterized by a higher binding affinity to ER-β as compared to estrogen receptor alpha (ER-α), the other estrogen receptor subtype.

Isoflavones inhibit intestinal epithelial cell proliferation and induce apoptosis in vitro

By reducing proliferation and inducing apoptosis, isoflavones may have a role in protecting normal intestinal epithelium from tumour development (reducing the risk) and may reduce colonic tumour growth.

Antioxidant efficacy of phytoestrogens in chemical and biological model systems.

The only estrogenic compound with significant antioxidant activity was kaempferol, better known as a dietary antioxidant than a phytoestrogen, which may indicate little significance as antioxidants in vivo.

Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer

The results indicate that raspberry phytochemicals likely to reach the colon are capable of inhibiting several important stages in colon carcinogenesis in vitro.

Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention

Repeated administration of bilberry anthocyanins exerts pharmacodynamic effects and generates concentrations of anthOCyanins in humans resembling those seen in ApcMin mice, a model of FAP adenomas sensitive to the chemopreventive properties of anthcyanins.