• Medicine
  • Published in
    Radiatsionnaia biologiia…
    2000

[The role of beta-adrenoreceptors in the mechanism of the hemodynamic action and radiation-protective activity of the copolymer of 2-methyl-5-vinylpyridine with 2-methyl-5-vinylpyridinium-N-oxide].

@article{Korovkina2000TheRO,
  title={[The role of beta-adrenoreceptors in the mechanism of the hemodynamic action and radiation-protective activity of the copolymer of 2-methyl-5-vinylpyridine with 2-methyl-5-vinylpyridinium-N-oxide].},
  author={E P Korovkina and P P Mikhaĭlov and I. B. Tsorin},
  journal={Radiatsionnaia biologiia, radioecologiia},
  year={2000},
  volume={40 4},
  pages={
          392-5
        }
}
In experiment on anesthetized dogs and cats in was shown that the new water-soluble copolymer initiated depressive reaction characteristic for beta-adrenomimetics. This effect was levelled with the help of non-selective adrenoblockator--propranololum. In experiment on dogs the preliminary treatment with propranololum decreased the therapeutic antiradiation efficiency of the copolymer from 68.4 to 8.3%.