[The pharmacology of biphosphonates and their use in hypercalcemia].

  title={[The pharmacology of biphosphonates and their use in hypercalcemia].},
  author={Z Weber Adam and Jir̆{\'i} Vorl{\'i}c̆ek and Miroslav Tom{\'i}{\vs}ka},
  journal={Vnitrni lekarstvi},
  volume={40 10},
Bisphosphonates, derivatives of pyrophosphates are substances which block the function of osteoclasts and thus break down bone. They can be administered by the oral and i.v. route. Oral treatment is limited by poor absorption which e.g. in clodronate varies between 1 - 5%. The long half-life of bisphosphonates adsorbed on bone makes it possible to achieve the desired effect by administration once in 1 - 3 months. Bisphosphonates are considered the most effective drugs for treatment of… CONTINUE READING

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