[The pharmacokinetics of josamycin].

@article{Wildfeuer1985ThePO,
  title={[The pharmacokinetics of josamycin].},
  author={Alexander Wildfeuer and J D Lemme},
  journal={Arzneimittel-Forschung},
  year={1985},
  volume={35 3},
  pages={
          639-43
        }
}
Determination of the distribution coefficients in vitro demonstrates that josamycin (Wilprafen) is at least 15 times more lipophilic than erythromycin. On the other hand the distribution coefficients of penicillin G and of amoxicillin be in the hydrophilic range. The serum protein binding of josamycin is 15%, which is markedly less than with the other macrolides. These in vitro experiments show that small structural differences can alter the physicochemical and biological behaviour of an… CONTINUE READING

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