• Corpus ID: 19460224

[The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910].

@article{Lin2006TheIO,
  title={[The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910].},
  author={Li-hong Lin and Hai-hua Huang and Peng Zhang and Da-fang Zhong},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  year={2006},
  volume={41 10},
  pages={
          967-72
        }
}
AIM To investigate the variation of CYP2C9 isoenzyme activity in the microbial model in response to inhibitors of CYP2C9. METHODS Using C. blakesleeana AS 3. 910 as a model strain, the impact of CYP2C9 inhibitors on the metabolites yields of CYP2C9 substrates was determined and the drug-drug interactions among CYP2C9 substrates were evaluated. Liquid chromatography-mass spectrometry was used to analyze biotransformation products. RESULTS Benzbromarone decreased the yield of 4…