[The entero-insular axis: the new incretin candidate glucagon-like peptide-1(7-36)amide (GLP-1(7-36))amide].

@article{Gke1988TheEA,
  title={[The entero-insular axis: the new incretin candidate glucagon-like peptide-1(7-36)amide (GLP-1(7-36))amide].},
  author={R{\"u}diger G{\"o}ke and Burkhard J. G{\"o}ke and Gerd Richter and Rudolf Arnold},
  journal={Zeitschrift fur Gastroenterologie},
  year={1988},
  volume={26 11},
  pages={715-9}
}
The functional connection between the gut and pancreatic islets is described by the term "enteroinsular axis". A humoral factor of the gut that might enhance the glucose-induced secretion of insulin is named "incretin". For many years glucose-dependent insulin-releasing polypeptide (GIP) was the strongest incretin candidate. However, recent evidence suggests that glucagon-like peptide-1(7-36)amide represents a more potent physiological incretin. The sequence of GLP-1 is identical in various… CONTINUE READING