[The endocrinologic profile of metabolites of the progestin dienogest].

  title={[The endocrinologic profile of metabolites of the progestin dienogest].},
  author={Michael Oettel and Guenter W. Kaufmann and A J Kurischko},
  journal={Die Pharmazie},
  volume={48 7},
Two identified metabolites of the orally active progestin dienogest, the compounds STS 749 (17 alpha-cyanomethyl-11 beta,17 beta-dihydroxy-estra-4,9-dien-3-one) and STS 825 (17 alpha-cyanomethyl-estra-1,3,5(10),9(11)-tetraene-3,17 beta-diol), furthermore 4 microbially formed metabolites and 10 chemically prepared analoga of dienogest were characterized by endocrinological tests. The compounds were investigated for progesterone-receptor binding, progestational and antiprogestational, estrogenic… CONTINUE READING

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