Corpus ID: 46244778

[The effects of valtrate on the EEG of the isolated, perfused rat brain].

@article{Fink1984TheEO,
  title={[The effects of valtrate on the EEG of the isolated, perfused rat brain].},
  author={C. Fink and J. H{\"o}lzl and H. Rieger and J. Krieglstein},
  journal={Arzneimittel-Forschung},
  year={1984},
  volume={34 2},
  pages={
          170-4
        }
}
The purpose of the present investigation was to prove the central activity of valtrate. In order to avoid biotransformation of valtrate the isolated perfused rat brain was used for this study. The CNS activity of the drug was characterized by EEG changes which were analysed visually and quantified by automatic methods. The following results were obtained: In the EEG of brains perfused with valtrate the normal background beta activity was interrupted by spikes and paroxysmal patterns of theta… Expand
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