[The effects of constituents of an antitussive and expectorant preparation on physical dependence on and antitussive activity of dihydrocodeine].

@article{Yoshii1990TheEO,
  title={[The effects of constituents of an antitussive and expectorant preparation on physical dependence on and antitussive activity of dihydrocodeine].},
  author={Toshio Yoshii and Yoshikazu Masukawa and Y Fukagawa and Tsutomu Suzuki and Miwa Misawa and Saizo Yanaura},
  journal={Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence},
  year={1990},
  volume={25 5},
  pages={419-28}
}
The effects of constituents of an antitussive and expectorant preparation on physical dependence potential and antitussive activity of dihydrocodeine (DC) were studied. Rats were treated with DC, methylephedrine (ME), chlorpheniramine (CP), and caffeine (CA) singly or simultaneously admixed with food (DC 0.125, ME: 0.25, CP: 0.05, CA: 0.25 mg /g of food) for 7 days. Subsequently, rats were treated with naloxone (0.5 mg/kg, sc) and withdrawal signs produced were observed. Naloxone-precipitated… CONTINUE READING