[The effects of RH 421 on the activity of amphotericin B in cell and model membranes].

@article{Mikhailova2013TheEO,
  title={[The effects of RH 421 on the activity of amphotericin B in cell and model membranes].},
  author={Ekaterina V. Mikhailova and Svetlana S Efimova and Olga S. Ostroumova},
  journal={Tsitologiia},
  year={2013},
  volume={55 2},
  pages={136-9}
}
The combined action of polyene macrolide antibiotic amphotericin B and styryl dye RH 421 in model lipid membranes and in yeast Saccharomyces cerevisiae has been studied. RH 421 insertion inti the ergosterol-containing lipid bilayers led to the increase of the steady-state number of open amphotericin channels by 8.5 +/- 3.2 times. Paper disk agar diffusion… CONTINUE READING