[The effect of ribozyme RzDS on duck hepatitis B virus].


To study the effect of ribozyme in vivo, the hammerhead ribozyme RzDS was designed and synthesized, which aims at the pregenome RNA of DHBV(LJ-76) at the 736 site of the genome. The RzDS cleaved efficiently its substrate in vitro. We constructed pJ-RzDS, in which RzDS was inserted into pJ120 plasmid under the control of PII promoter. After homogenous… (More)


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@article{Li1998TheEO, title={[The effect of ribozyme RzDS on duck hepatitis B virus].}, author={H Li and Wufan Chen and W. Xu}, journal={Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology}, year={1998}, volume={12 2}, pages={118-21} }