[The effect of rectal pH values on the absorption of methohexital].

@article{Jantzen1986TheEO,
  title={[The effect of rectal pH values on the absorption of methohexital].},
  author={Jochem Jantzen and Karin Erdmann and P K Witton and Adam M. Klein},
  journal={Der Anaesthesist},
  year={1986},
  volume={35 8},
  pages={496-9}
}
The factors underlying the unpredictability of the pharmacokinetics of rectally administered methohexitone remain unclear. The "pH partition hypothesis" offers an explanation. We investigated six children with rectal pH values ranging from 7.5 to 9.8, who were given 25 mg/kg methohexitone 10% via the rectal route under general anaesthesia. Blood samples were taken at zero, 3, 5, 7, 10, 15, 20, 30, 40, 60, 90 and 120 min; rectal pH was measured at zero and 1 min. The methohexitone plasma levels… CONTINUE READING