• Corpus ID: 28418928

[The effect of long-term nitrazepam administration on sleep cycles in rats].

@article{Klygu1976TheEO,
  title={[The effect of long-term nitrazepam administration on sleep cycles in rats].},
  author={T A Klygu' and O Kadletsova and Iu I Vikhliaev},
  journal={Biulleten' eksperimental'noi biologii i meditsiny},
  year={1976},
  volume={81 2},
  pages={
          188-90
        }
}
Single and chronic administration of a low dose of nitrazepam (1 mg/kg) had no effect on sleep cycles in rats. A single injection of a high dose (10 mg/kg) of nitrazepam resulted in prolongation of the total duration of synchronized sleep with a corresponding shortening of desynchronized (paradoxical) sleep. The number of sleep cycles was reduced. Chronic injections of nitrazepam (for 7-14 days) in a dose of 10 mg/kg evoked a gradual prolongation of the duration of paradoxical sleep and an… 
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