Corpus ID: 31826372

[The effect of isoflurane on plasma concentration-response curve of vecuronium determined with continuous infusion method].

@article{Oku1993TheEO,
  title={[The effect of isoflurane on plasma concentration-response curve of vecuronium determined with continuous infusion method].},
  author={Shiro Oku},
  journal={Masui. The Japanese journal of anesthesiology},
  year={1993},
  volume={42 3},
  pages={
          328-38
        }
}
  • S. Oku
  • Published 1993
  • Medicine
  • Masui. The Japanese journal of anesthesiology
To investigate the interaction between vecuronium and isoflurane at the neuromuscular junction in man, I determined the plasma concentration-response curve of vecuronium both under balanced and isoflurane (0.7% and 1.2% end-tidal) anesthesia. In addition, I also determined clinically the infusion rate of vecuronium that made a suitable sustained relaxation possible. I used train-of-four (TOF) stimulation to monitor neuromuscular blockade by vecuronium. Plasma isoflurane concentration was kept… Expand