[The construction and identification of the PRNP vectors with ubiquitin or the lysosome-targeting signal].

Abstract

OBJECTIVE To evaluate PrP expression characteristic of PRNP nucleic acid vaccine vector with ubiquitin or the lysosome-targeting signal. METHODS The gene of ubiquitin and lysosome-targeting signal were ligated to PRNP and pcDNA3.1 vector that is, pcDNA3.1-UPrP and pcDNA3.1-PrPL were constructed. The expression characteristics of PrP with two signals were… (More)

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