[The concentration of noradrenalin and adrenalin in isolated sections of the heart].

@article{Muscholl1959TheCO,
  title={[The concentration of noradrenalin and adrenalin in isolated sections of the heart].},
  author={Erich Muscholl},
  journal={Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie},
  year={1959},
  volume={237},
  pages={
          350-64
        }
}
  • E. Muscholl
  • Published 1959
  • Biology, Medicine
  • Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie
1. A method for the assay of noradrenaline and adrenaline in small pieces of heart tissue is described. The amines were extracted with acid ethanol and separated by paper chromatography. The regions containing the amines were eluted and the amount of amines in the eluates was determined by bioassay. Noradrenaline was assayed on the blood pressure of the pithed rat. Adrenaline was assayed on the isolated atropinized rat's uterus stimulated with oxytocin. 2. The identity of the… 
EVIDENCE FOR NORADRENALINE AND ADRENALINE AS SYMPATHETIC TRANSMITTERS IN THE CHICKEN
TLDR
It was found that the cardio‐vascular potency of noradrenaline, as reflected by the increases in heart rate, cardiac tension development and arterial blood pressure, was not significantly different from that of adrenaline.
Effect of cocaine and related drugs on the uptake of noradrenaline by heart and spleen.
  • E. Muscholl
  • Biology, Medicine
    British journal of pharmacology and chemotherapy
  • 1961
TLDR
It was concluded that cocaine specifically prevented the uptake of noradrenaline by tissues, thus increasing the amount of norADrenaline available for combination with adrenergic receptors.
Catecholamine release from the isolated perfused adrenal gland
TLDR
It is concluded that the nature of the releasing agent and not the composition of the adrenal stores plays a decisive role in determining the relative proportion of the amounts of adrenaline and noradrenaline released.
Untersuchungen über die Noradrenalin-Freisetzung durch Acetylcholin am perfundierten Kaninchenherzen
  • K. Löffelholz
  • Chemistry
    Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie
  • 2004
SummaryThe following experiments were done in order to study the effects of alterations in the ionic composition of the perfusion fluid of the isolated rabbit heart on the noradrenaline release
Effect of drugs on the noradrenaline content of brain and peripheral tissues and its significance.
  • S. Sanan, M. Vogt
  • Biology, Chemistry
    British journal of pharmacology and chemotherapy
  • 1962
TLDR
Results show that prolonged administration of the mono-amine oxidase inhibitors pheniprazine and phenylhydrazinobutane raised the noradrenaline content of the brain of rabbits but not that of cats, whereas it raised the Noradrenalin of the ganglia of cats but not (or rarely) that of rabbits.
Regional Distribution of Catecholamines in the Dog Heart
TLDR
It is concluded that no sample of the heart can be considered as representative of the entire organ, and that the catecholamine content of the whole heart cannot be taken as reflecting the concentrations in various specific areas.
The extent of neuronal re-uptake of 3H-noradrenaline in isolated vasa deferentia and atria of the rat
TLDR
Fractional rates were calculated on the basis of a mathematical model of the adrenergic nerve ending for unidirectional outward diffusion, for outward transport and for neuronal re-uptake for 3H-noradrenaline and found that the density of adrenergic innervation is lower in atria than in vasa deferentia.
Die Wirkung von Reserpin auf die Konzentration von Adrenalin und Noradrenalin im Katzenherz
  • E. Muscholl
  • Biology
    Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
  • 2004
TLDR
Observations suggest that the adrenaline of the heart behaves differently from that of sympathetic ganglia or postganglionic nerve fibres after an injection of reserpine, while in ganglia and nerve fibre the adrenaline concentration is not significantly affected by reser Pine.
...
...

References

SHOWING 1-10 OF 22 REFERENCES
The quantitative separation of adrenaline and noradrenaline in biological fluids and tissue extracts.
TLDR
It will be evident that the estimates of adrenaline and noradrenaline are interdependent.
A method for the fluorimetric determination of adrenaline and noradrenaline in tissues.
TLDR
A method for chemical assay of small amounts of adrenaline and noradrenaline in tissues is described, utilizing the difference in the activation spectra of the fluoro-phores to identify the two amines.
The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs
  • M. Vogt
  • Biology
    The Journal of physiology
  • 1954
TLDR
The presence of noradrenaline and adrenaline in the brain has been demonstrated by von Euler and Holtz and the question whether these sympathomimetic amines, besides their role as transmitters at vasomotor endings, play a part in the function of the central nervous tissue itself is concerned.
Separation of NorAdrenalin and Adrenalin
TLDR
On repeating their experiment, von Euler and Hamberg found that movement was very little greater than in the original n-butanol – water system, and that, to obtain separation, the chromatogram had to be run for forty-eight hours or longer, allowing the solvent to drip from the end of the paper.
The Distribution of Sympathin N and Sympathin A in Spleen and Splenic Nerves of Cattle
TLDR
The results are in favour of the assumption that the noradrenaline in the nerves is partly methylated, this process being more intense in the peripheral parts of the nerves.
The secretion of the denervated adrenal medulla of the cat.
  • M. Vogt
  • Biology
    British journal of pharmacology and chemotherapy
  • 1952
In 1917 Stewart and Rogoff tried to determine whether the chronically denervated adrenal medulla shows any secretory activity. They came to the conclusion that " no epinephrine is normally released
l-norAdrenaline in the Suprarenal Medulla
TLDR
The present report confirms the findings of the previous report that adrenal medullary tumours contain a high proportion of noradrenaline, and confirms these findings with the use of different techniques.
Identification and chemical assay of norepinephrine in brain and other tissues.
  • P. A. Shore, J. Olin
  • Chemistry, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1958
Norepinephrine has been identified chemically as a normal constituent of brain. A simple, rapid fluorometric method for the estimation of catechol amines in brain and other tissues is described. The
A New Type of Chromaffin Cells, probably storing Dopamine
TLDR
Thevon Euler and Lishajko concluded that dopamine in the lung cannot merely be an intermediate metabolite in the synthesis of noradrenaline in the adrenergic axons.
Distribution of Norepinephrine in the Heart
THE concentrations of norepinephrine found by various investigators in the hearts of different animal species are summarized in the 1956 monograph by von Euler1. These values range from 0.3 to 1.0
...
...