[The cloning of human Smac gene and its pro-apoptotic effect on Burkitt's lymphoma cells].

Abstract

OBJECTIVE Second mitochondria-derived activator of caspase (Smac) is a recently identified, novel pro-apoptotic molecule, which is released from mitochondria into the cytosol during apoptosis. Smac promotes activation of caspases by neutralizing members of the inhibitor of apoptosis proteins (IAPs) family, such as X-linked inhibitor of apoptosis protein… (More)

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