[The blocking effects of extracellular Mn2+ on the inward rectifier potassium channel (IRK1)].

AIM AND METHODS Two-microelectrode voltage clamp (TEV) method was used to study the blocking effects of extracellular Mn2+ on the inward rectifier potassium channel (IRK1) expressed in the Xenopus oocytes. RESULTS Mn2+ can concentration-, time- and vol-tage dependently block IRK1 instantaneous currents (2 ms after voltage applied). Mn2+ has almost no… CONTINUE READING