[The application of RNAi technology in transgenic mice].

@article{Yin2006TheAO,
  title={[The application of RNAi technology in transgenic mice].},
  author={X J Yin and Ling-qiang Zhang and Fu-chu He},
  journal={Yi chuan = Hereditas},
  year={2006},
  volume={28 3},
  pages={351-6}
}
RNA interference (RNAi) has been extensively used for sequence-specific silencing of gene function in C. elegans, Drosophila, mouse and rat. The generation of RNAi transgenic mice made it possible to knock down gene expression at the whole organism level in mammalian species. In this review we described the design strategy of RNAi vectors, compared the… CONTINUE READING