[The anxiolytic effect of ondansetron and its capacity to eliminate the benzodiazepine abstinence syndrome in rats].

Abstract

Ondansetron (GR38032F, zofran)--a specific blocker of 5-HT3-receptors in a dose range of 0.05 to 0. mg/kg causes an anxiolytic effect in experiments on mice and rats on a model of elevated plus maze. The drug does not produce a sedative and myorelaxant effect. A 0.05 mg/kg dose of ondansetron reduces the level of anxiety and convulsive manifestations which… (More)

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@article{Garibova1999TheAE, title={[The anxiolytic effect of ondansetron and its capacity to eliminate the benzodiazepine abstinence syndrome in rats].}, author={T. L. Garibova and T. A. Voronina and V. A. Kraineva and Elena Val'dman}, journal={Eksperimental'naia i klinicheskaia farmakologiia}, year={1999}, volume={62 6}, pages={16-9} }