[The amiloride sensitive sodium channel].

  title={[The amiloride sensitive sodium channel].},
  author={Pascal Barbry and Guy Champigny and Eric Lingueglia and Nicolas Voilley and Rainer Waldmann and Michel Lazdunski},
  volume={17 7},
The amiloride-sensitive epithelial Na+ channel is formed by the assembly of three homologous subunits alpha, beta and gamma. The channel is characterized by its sensitivity to amiloride and to some amiloride derivatives, such as phenamil and benzamil, by its small unitary conductance (approximately 5pS), by its high selectivity for lithium and sodium, and by its slow kinetics. The alpha, beta, and gamma proteins share significant identity with degenerins, a family of proteins found in the… CONTINUE READING