[The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese].

@article{Sun2005TheCP,
  title={[The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese].},
  author={Yan Sun and Jia-jun Shi and Si-zhong Zhang and Mu-ni Tang and Hai-ying Han and Yang-bo Guo and Cui Ying Ma and Xie-he Liu and Tao Li},
  journal={Yi chuan = Hereditas},
  year={2005},
  volume={27 2},
  pages={190-4}
}
Cathepsin D is the major lysosomal/endosomal aspartic protease and exhibits beta- and gamma-secretase-like activity in vitro. Data from German suggest that the C224T polymorphism in the Cathepsin D gene (CTSD) exon 2 is strongly associated with the risk for Alzheimer's disease (AD). Meanwhile other studies have not been able to replicate the result. It's necessary to determine the genotype of the polymorphism in CTSD in Chinese sporadic AD patients and age-matched controls with normal cognition… CONTINUE READING

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