[Telomerase downregulation during differentiation of leukemia cells].

@article{Seimiya1998TelomeraseDD,
  title={[Telomerase downregulation during differentiation of leukemia cells].},
  author={Hiroyuki Seimiya and Takashi Tsuruo},
  journal={Nihon rinsho. Japanese journal of clinical medicine},
  year={1998},
  volume={56 5},
  pages={1121-5}
}
Telomerase activity is often repressed during terminal differentiation of immortal cells. We found that activation of mitogen-activated protein kinase (MAPK) itself was not sufficient for telomerase downregulation during phorbol ester-induced differentiation of leukemia U937 cells whereas a MEK1 inhibitor PD98059 inhibited both the differentiation and… CONTINUE READING