[Systemic therapy for metastatic renal cell carcinoma].

  title={[Systemic therapy for metastatic renal cell carcinoma].},
  author={Mario Wolfgang Kramer and Sandra Steffens and C-A von Klot and Axel Stuart Merseburger and Markus Antonius Kuczyk},
  journal={Aktuelle Urologie},
  volume={43 4},
A better understanding of molecular biological mechanisms involved in the pathogenesis or, respectively, prognosis of renal cell carcinoma has recently led to a fundamental change in those therapeutic options that are especially effective after systemic disemination. In this context, cytokine-based therapeutic concepts have been replaced by the so-called targeted therapeutic agents that include, above all, tyrosine kinase (TK) and mTOR inhibitors. The present contribution is intended to reflect… CONTINUE READING