Corpus ID: 88968470

[Synthesis of spin-labeled rubomycin and a study of its interaction with DNA].

@article{Ls1979SynthesisOS,
  title={[Synthesis of spin-labeled rubomycin and a study of its interaction with DNA].},
  author={Povarov Ls and Grigorian Gl and Isaeva Nn and Suskina Vi},
  journal={Antibiotiki},
  year={1979},
  volume={24},
  pages={488}
}
: Hydrochloride of 14-(I-oxyl-2,2,6,6-tetramethylpiperidyl-4)-acetoxyrubomycin (spin-labeled rubomycin or SL-rubomycin) was prepared by interaction of hydrochloride of 14-bromrubomycin with potassium salt of I-oxyl-2,2,6,6-tetramethylpiperidyl-4-acetic acid. Its interaction with DNA and synthetic poly A and poly U polyribonucleotides was studied. The character of the EPR spectra was indicative of DNA binding with SL-rubomycin and forming a system with a high level of regularity similar to that… Expand
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Recent studies on doxorubicin and its analogues.
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This chapter focuses on synthetic routes to doxorubicin and other anthracyclines and discusses the biochemical effects of dox orubic in and analogues of doXorubICin. Expand