Corpus ID: 26902449

[Synthesis of 18F-FDG with FDG MicroLab system: basic studies for clinical application].

@article{Kuge1999SynthesisO1,
  title={[Synthesis of 18F-FDG with FDG MicroLab system: basic studies for clinical application].},
  author={Y. Kuge and E. Tsukamoto and C. Katoh and K. Seki and K. Ohkura and Y. Ohmiya and K. Nishijima and A. Tanaka and M. Sasaki and N. Tamaki},
  journal={Kaku igaku. The Japanese journal of nuclear medicine},
  year={1999},
  volume={36 8},
  pages={
          873-8
        }
}
We synthesized 18F-FDG by using an automated synthetic apparatus "FDG MicroLab" (GE Medical Systems) which produces 18F-FDG by a solid phase 18F-fluorination. Its quality and reproducibility were evaluated in order to assess feasibility of the apparatus for routine clinical production of 18F-FDG. For 5 consecutive 18F-FDG synthesis, target irradiation was carried out at 15 microA for 60 min. 18F-FDG was obtained in 50 min after EOB with an end-of-synthesis yield of 9.34 +/- 1.06 GBq… Expand
4 Citations
Chemical impurities in [18F]FDG preparations produced by solid-phase 18F-fluorination.
TLDR
The levels of several chemical impurities were determined in the [18F]FDG preparations produced by solid-phase 18F-fluorination and no notable radiochemical impurities, including 2-[18F]-fluoro-2-deoxy-D-mannose, were detected in the preparations. Expand
Radiopharmaceutical Production and Safety of [18F]FDG
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Increased [18F]2-fluoro-2-deoxy-D-glucose ([18F]FDG) yield with recycled target [18O]water: factors affecting the [18F]FDG yield.
  • K. Nishijima, Y. Kuge, +6 authors N. Tamaki
  • Chemistry, Medicine
  • Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • 2002
TLDR
Levels of several ionic impurities including Cl- and Ca2+ were significantly higher in the virgin [18O]water than in the recycled water, while significantly larger amounts of organic impurities were detected in the former, Hence, trace amounts of organics were not responsible for the lower [18F]FDG yield. Expand
Tritium in [18O]water containing [18F]fluoride for [18F]FDG synthesis.
TLDR
Tritium was detected in enriched [18O]water irradiated with 9.6 MeV protons used to produce [18F]fluoride by the 18O(p, n)18F reaction, and the existence of tritium was confirmed experimentally. Expand